Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods by Augustine Amalraj

Author:Augustine Amalraj
Language: eng
Format: epub
ISBN: 9780323998147
Publisher: Elsevier Ltd.
Published: 2022-11-19T08:41:54+00:00

The healthy human placenta is necessary for successful pregnancy. Studies showed that oxidative stress led to dysfunction placenta and pregnancy issues. Pomegranate juice and punicalagin showed decrease in trophoblast injury in vivo and in vitro. The study was conducted in 12 pregnant patients. Four patients received 8oz./day of pomegranate juice, and eight patients were given apple juice (placebo). There was a significant decrease in oxidative stress in human placental tissue with patients who labored on pomegranate juice than on apple juice. Also, pomegranate juice reduced the apoptosis, oxidative stress, and cell death in hypoxia exposed to villous explants and primary trophoblast cultures. The polyphenol punicalagin showed more pronounced stimulus-induced apoptosis as compared to other polyphenol ellagic acid in cultured syncytiotrophoblasts [113].

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